منابع مشابه
Refining Protein Subcellular Localization
The study of protein subcellular localization is important to elucidate protein function. Even in well-studied organisms such as yeast, experimental methods have not been able to provide a full coverage of localization. The development of bioinformatic predictors of localization can bridge this gap. We have created a Bayesian network predictor called PSLT2 that considers diverse protein charact...
متن کاملProtein Subcellular Localization Prediction
ORGANIZATION. Section 1. We first provide the motivation for prediction of protein subcellular localization sites, as well as discuss changes being brought about by progress in proteomics. Section 2. After that, we describe the biology of protein subcellular location. In particular, we explain the principle of protein sorting signals. Section 3. Then we present several experimental techniques f...
متن کاملPrediction of protein subcellular localization.
Because the protein's function is usually related to its subcellular localization, the ability to predict subcellular localization directly from protein sequences will be useful for inferring protein functions. Recent years have seen a surging interest in the development of novel computational tools to predict subcellular localization. At present, these approaches, based on a wide range of algo...
متن کاملProtein subcellular localization in bacteria.
Like their eukaryotic counterparts, bacterial cells have a highly organized internal architecture. Here, we address the question of how proteins localize to particular sites in the cell and how they do so in a dynamic manner. We consider the underlying mechanisms that govern the positioning of proteins and protein complexes in the examples of the divisome, polar assemblies, cytoplasmic clusters...
متن کاملSubcellular localization of the retinoblastoma protein.
The subcellular localization of the retinoblastoma (RB) protein has been studied in primate cell lines by immunofluorescence staining using different monoclonal and polyclonal antibodies. The protein appeared as granules of heterogeneous size over the interphase nuclei. Computer assisted digital overlap analysis indicated that it was predominantly localized in euchromatic areas with low DNA den...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2005
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.0010066